Recrystallize the maleic anhydride from toluene. Acute (short-term) inhalation exposure of humans to maleic anhydride has been observed to cause irritation of the respiratory tract and eye irritation. Moisture sensitive. Maleic anhydride is a colorless to white solid that forms orthorhombic crystals and decomposes in water. Causes chemical burns to the respiratory tract. SAFETY DATA SHEET SECTION 1: Identification of the substance/mixture and of the company/undertaking 1.1. : 108-31-6 1.2 Relevant identified uses of the substance or mixture and uses advised against Identified uses : Laboratory chemicals, Manufacture of substances 1.3 Details of the supplier of the safety data sheet May cause allergic skin and respiratory reaction. Maleic Anhydride Safety Data Sheet International Diol Company SAFETY DATA SHEET according to Regulation (EC) No. System RfD (mg/kg-day) Basis PoD Composite UF Confidence; Urinary: 1 x 10 -1: Renal lesions: NOAEL : 1.0 x 10 1 mg/kg-day Harmful if swallowed. (2) Conversion Factors: The anhydride of maleic acid has five atoms in its cyclic molecule, the unsaturated bond undergoes free radical polymerization in the presence of an initiator. none Water, Foam, Alcohol resistant foam, ABC-powder Water jet Nitrogen oxides (NOx), Carbon monoxide (CO), Carbon dioxide (CO2) In … Target Organs: Lungs, respiratory system, eyes, Washington, DC: Manufacturing Chemists Association, p. 1-13. Stir the mixture for 10 min. The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website. FIRST AID MEASURES General advice Consult a physician. Click here for information on selection of N, R, or P filters.Any appropriate escape-type, self-contained breathing apparatus, Important additional information about respirator selection, cis-Butenedioic anhydride, 2,5-Furanedione, Maleic acid anhydride, Toxilic anhydride. Up to 10 mg/m3: (APF = 25) Any supplied-air respirator operated in a continuous-flow mode£(APF = 50) Any self-contained breathing apparatus with a full facepiece(APF = 50) Any supplied-air respirator with a full facepiece, Emergency or planned entry into unknown concentrations or IDLH conditions: (APF = 10,000) Any self-contained breathing apparatus that has a full facepiece and is operated in a pressure-demand or other positive-pressure mode(APF = 10,000) Any supplied-air respirator that has a full facepiece and is operated in a pressure-demand or other positive-pressure mode in combination with an auxiliary self-contained positive-pressure breathing apparatus, Escape: (APF = 50) Any air-purifying, full-facepiece respirator (gas mask) with a chin-style, front- or back-mounted organic vapor canister having an N100, R100, or P100 filter. Chemical name :maleic anhydride Substance/mixture : Occupational exposure limits, if available, are listed in Section 8. May cause asthmatic attacks due to allergic sensitization of the Colorless needles, white lumps, or pellets with an irritating, choking odor. The odour warning when the exposure limit value is exceeded is insufficient. Common Name Maleic Anhydride Synonym(s) 2,5Furandione Formula C 4 H 2 O 3 CAS Number 108316 COMPONENT CAS NUMBER CONCENTRATION Maleic Anhydride 108316 ≤ Section 4. Strong oxidizers, water, alkalis, metals, caustics & amines above 150°F pain. Chronic: Safety Data Sheet 24 hour Emergency Response No. Add 0.98 g (0.01 mole) of maleic anhydride to a solution of 1.67 g (0.01 mole) of veratrylamine in 10 mL of chloroform. Skin: SAFETY DATA SHEET (in accordance with Regulation (EU) 2015/830) 108120-Maleic anhydride Version: 3 Revision date: 19/04/2016 Page 2 of 9 Print date: 19/04/2016 -Continued on next page.- P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing. Causes redness and Linking to a non-federal website does not constitute an endorsement by CDC or any of its employees of the sponsors or the information and products presented on the website. Prolonged or repeated skin contact may cause dermatitis. Pesticide properties for Maleic hydrazide, including approvals, environmental fate, eco-toxicity and human health issues tract irritation and possible burns. Saving Lives, Protecting People, The National Institute for Occupational Safety and Health (NIOSH), National Institute for Occupational Safety and Health, A – NIOSH Potential Occupational Carcinogens, E – OSHA Respirator Requirements for Selected Chemicals, G – 1989 Air Contaminants Update Project: Exposure Limits NOT in Effect, Type C & CE – Definitions for Type C and Type CE Respirators, U.S. Department of Health & Human Services. The ‘Hazard classification and labelling’ section shows the hazards of a substance based on the standardised system of statements and pictograms established under the CLP (Classification Labelling and Packaging) Regulation. Maleic anhydride, polymers Safety Profile. Histological examination revealed nephrosis which increased in severity with the dose above 100 mg/kg. (5,8) The vapor pressure for maleic anhydride is 0.1 to 0.2 mm Hg at 25 °C. Causes severe eye and skin irritation with possible Causes gastrointestinal tract burns. Maleic anhydride TWA: 0.01 mg/m 3(Vacated) TWA: 0.25 ppm (Vacated) TWA: 1 mg/m3 TWA: 0.25 ppm TWA: 1 mg/m3 IDLH: 10 mg/m TWA: 0.25 ppm TWA: 1 mg/m3 TWA: 0.01 ppm Legend ACGIH - American Conference of Governmental Industrial Hygienists OSHA - Occupational Safety and … Inhalation of high concentrations may cause pulmonary edema. ], inhalation, ingestion, skin and/or eye contact, irritation nose, upper respiratory system; conjunctivitis; photophobia (abnormal visual intolerance to light), double vision; bronchial asthma; dermatitis, Centers for Disease Control and Prevention. Immediate medical attention is required. Consult a physician. Wear safety goggles or eye protection in combination with breathing protection if powder. Reproductive Toxicity: No data available Reproductive toxicity - Rat - Oral double vision, and "halo" vision. A combination of these processes should be important. Polynt Group produces a great variety of anhydrides, but the most important ones are: Phthalic Anhydrides, Maleic Anhydride, Trimellitic Anhydride CDC is not responsible for Section 508 compliance (accessibility) on other federal or private website. Maleic anhydride is used in the formulation of resins. Symptoms and effects are not known to date. Causes redness and pain. You will be subject to the destination website's privacy policy when you follow the link. "Maleic Anhydride, Maleic Acid, and Fumaric Acid." Inhalation: If inhaled If breathed in, move person into fresh air. Eye Contact Rinse immediately with plenty of water, also under the eyelids, for at least 15 minutes. Maleic Anhydride 95 - 100% 108-31-6 Get medical attention immediately. National Cancer Institute, June 17, 1974. If not breathing, give artificial respiration. Anhydrides. 5. Since it biodegrades in sewage treatment plants and hydrolyzes, it's likely that it will degrade in soil. Rinse mouth with water (only if the person is conscious). Product identifier Identification number Name of the substance Maleic anhydride 607-096-00-9 (Index number) Registration number 01-2119472428-31 Synonyms MAN Issue date 07-March-2019 Version number 01 Revision date-Supersedes date-1.2. Maleic anhydride released into water will hydrolyze rapidly (half-life 0.37 min) to maleic acid. Maleic anhydride CAS -No. Since it biodegrades in sewage treatment plants and hydrolyzes, it's likely that it will degrade in soil. Product name : Maleic Anhydride CAS-No. : 108-31-6 1.2 Relevant identified uses of the substance or mixture and uses advised against Identified uses : Laboratorychemicals, Industrial & for professional use only. reaction, which becomes evident upon re-exposure to this material. Index -No. When heated to decomposition it emits acrid smoke and irritating vapors. Maleic anhydride has several uses, almost all of them related to the synthesis of other chemicals as fumaric and tartaric acids, certain agricultural chemicals (i.e., maleic hydrazide, malathion), lubricants, surface active agents, resins in different products, dye intermediates, pharmaceuticals, and more. CDC twenty four seven. Potential Health Effects Interagency Collaborative Group on Environmental Carcinogens. Since it biodegrades in sewage treatment plants and hydrolyzes, it's likely that it will degrade in soil. Maleic acid 110-16-7 >95 4. respiratory tract. Product Identification Synonyms: cis-Butenedioic anhydride; 2,5-furandione; toxilic anhydride CAS No. Wash out mouth with water. : 108-31-6 Molecular Weight: 98.06 Chemical Formula: C4H2O3 Company: ADDTEK CHEMICAL SHANGHAI CO LTD TEL: +86 21 63352916 FAX: +86 21 51010033EXT8839 exposure may cause allergic respiratory reaction (asthma). Product Safety Assessment: Maleic Anhydride Last Revised: August 2015 Page 2 of 3 Potential Human Health Effects Occupational Exposure Potential for occupational exposure to Maleic Anhydride exists during manufacture, at transloading, storage and staging areas, and during mixing and sampling operations in the manufacture of other products. May cause conjunctivitis. Eye: MALEIC ACID page 2 of 6 This Fact Sheet is a summary source of information of all ... (as Maleic Anhydride) exists, use a MSHA/NIOSH approved self-contained breathing apparatus with a full facepiece operated in a … Exposure to high fume concentrations cause photophobia, Remove victim to fresh 1272/2008, Regulation (EC) No.1907/2006 Maleic Anhydride, rev 2 7/2012 Page 2 Basis for Classification This substance is classified based on Directive 1272/2008/EC and its amendments (CLP Regulation,GHS) MALEIC ANHYDRIDE (108-31-6) Environmental: Maleic anhydride's fate in soil is unknown. 1.3 Details of the supplier of the safety data sheet Company : Central Drug House (P) Ltd 7/28 Vardaan House New Delhi-10002 INDIA Memorandum. skin. Dissolve the residue in a minimal amount of chloroform. Harmful if swallowed. Safety Data Sheet (Maleic Anhydride) DATE PREPARED: 9/3/2015 Page 7 of 9 OSHA: No component of this product, present at levels greater than or equal to 0.1%, is identified as a carcinogen or potential carcinogen by OSHA. (2) Maleic anhydride has an acrid odor, with an odor threshold of 0.32 parts per million (ppm). burns. cis-Butenedioic anhydride, 2,5-Furanedione, Maleic acid anhydride, Toxilic anhydride Colorless needles, white lumps, or pellets with an irritating, choking odor. 108 -31 -6 203 -571 -6 607 -096 -00 -9 - 4. Ingestion: Maleic anhydride in daily doses of 20, 40,100, 250 or 600 mg/kg body weight, fed for 90 days to groups of 15 rats of each sex, caused macroscopic changes in the kidneys: enlargement and pale yellow discoloration. Hazard classification & labelling Hazard classification and labelling. Evaporate the chloroform in a hood. Show this safety data sheet to the doctor in attendance. A poison by intravenous route. First Aid Measures Description of Firstaid Measures General Advice: Consult a physician. irritation with nausea, vomiting, and diarrhea. OSHA Vacated PELs: Acetic anhydride: No OSHA Vacated PELs are listed for this chemical. Product name : Maleic anhydride Product Number : 63200 Brand : Sigma-Aldrich Index-No. ... Maleic anhydride is transported also as hot liquid (70°C); contact of the skin should be avoided. May cause skin sensitization, an allergic NCI [1974]. MATERIAL SAFETY DATA SHEET MALEIC ANHYDRIDE 1. Danger! Corrosive. First-aid measures General Advice Show this safety data sheet to the doctor in attendance. safety hazards of Maleic Acid to potentially exposed workers. +86-532-8027466 SECTION 1: PRODUCT AND COMPANY IDENTIFICATION ... Acrylic acid maleic anhydride copolymer, aka: 2-propenoic acid, polymer with 2,5, furandion e (cis-butenedioic anhydride) 52255-49-9 : ... Acrylic Acid Maleic … Appearance: white lumps. May cause digestive tract Chem., 1979, 179, C19], and is considered an excellent dieneophile for Diels-Alder reactions [Felthouse, Timothy R. et al. : 607-096-00-9 CAS-No. Show this safety data sheet to the doctor in attendance.Move out of dangerous area. Substance Any concentration shown as a range is to protect confidentiality or is due to batch variation. Maleic anhydride undergoes a potentially explosive exothermic Diels-Alder reaction with 1-methylsilacyclopenta-2,4-diene at 150C [Barton, T. J., J. Organomet. MCA [1974]. Box 219, Batavia, IL 60510 (800) 452-1261 Chemtrec Emergency Phone Number: (800) 424-9974 Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in … Risk Statements: 36/37/38 R36/37/38:Irritating to eyes, respiratory system and skin. Causes respiratory Causes eye burns. Move out of dangerous area. Chemical safety data sheet sd-88: properties and essential information for safe handling and use of maleic anhydride. Safety Statements :26-36/37/39 6. Exposure to maleic anhydride may occur from accidental releases to the environment or in workplaces where it is produced or used. 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