We comply with the HONcode standard for trustworthy health information -. Some side effects may not be reported. Cerner Multum, Inc. "Australian Product Information." Ondansetron is a common medication that can be used to treat vomiting in dogs and cats. O 0. Many times, it is used for people receiving cancer treatments, such as radiation therapy or chemotherapy. More common side effects. Data sources include IBM Watson Micromedex (updated 7 Dec 2020), Cerner Multum™ (updated 4 Dec 2020), ASHP (updated 3 Dec 2020) and others. A causal relationship to therapy with ondansetron hydrochloride has been unclear in many cases. It can be given by mouth or by injection into a muscle or into a vein. Applies to ondansetron: film, solution, tablet, tablet disintegrating. Bronchospasm 6. SIDE EFFECTS: Headache, lightheadedness, dizziness, drowsiness, tiredness, or constipation may occur. Note: This document contains side effect information about ondansetron. Common side effects of Zofran include headache, feeling unwell (malaise), fatigue, drowsiness, constipation, dizziness, and diarrhea. All rights reserved. It is not covered by most Medicare and insurance plans, but manufacturer and pharmacy coupons can help offset the cost. "Product Information. At the extreme end, the use of the drug caused fetal death including miscarriage and stillbirth. In the ondansetron prescribing label information (Zofran®, Zofran ODT® package insert), the most commonly reported ondansetron (Zofran®, Zofran ODT®) side effects are shown here. difficulty with passing urine (dribbling), puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue, dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position, increased blinking or spasms of the eyelid, large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs, uncontrolled twisting movements of the neck, trunk, arms, or legs, difficulty having a bowel movement (stool), uncontrolled movements, especially of the face, neck, and back, redness of the face, neck, arms, and occasionally, upper chest. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment. Ondansetron is a moderately priced drug used to treat nausea and vomiting caused by chemotherapy.It is also used to prevent or treat nausea and vomiting after surgery. Abnormal Heart Electrical Signals 2. In clinical trials of patients taking Zofran to prevent nausea and vomiting associated with chemotherapy, nearly a quarter of patients taking 8 mg of the drug twice daily experienced a headache. Transient, asymptomatic increases in AST/ALT 2 times the upper limit of normal commonly occurred in patients receiving chemotherapy with cisplatin, and did not appear to be related to dose/duration of treatment. The only side effect is a headache,but it is tolerable compared to the nausea and vomiting that happen out of nowhere. Zofran (ondansetron)." Zofran side effects Get emergency medical help if you have any of these signs of an allergic reaction to Zofran: rash, hives; fever, chills, difficult breathing; swelling of your face, lips, tongue, or throat. Ondansetron, sold under the brand name Zofran among others, is a medication used to prevent nausea and vomiting caused by cancer chemotherapy, radiation therapy, or surgery. 4. Zofran is linked to possible side effects, some of which are serious, including serotonin syndrome and QT interval prolongation. 3. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Side Effects. Slow Heartbeat 14. What Is Ondansetron? Many pregnant women have relied on anti-nausea medications to get them through the first few months of pregnancy, when nausea is at its peak. Last updated on Nov 11, 2020. The effects of Zofran were never investigated in clinical trials that included pregnant women, and thus there are no clinical trials targeting pregnant women that would provide us with a way of knowing what side effects it may cause in them or harm it may do to developing babies. WebMD does not provide medical advice, diagnosis or treatment. Medically reviewed by Drugs.com. Studies have linked Zofran to severe side effects, including birth defects, heart defects, cleft palate, and more. Oculogyric crisis occurred alone and in combination with other dystonic reactions. A myriad of women have come forward after experiencing adverse effects after taking the medication. Fast Heartbeat 9. Potential pregnancy side effects of Zofran have been linked to an increased risk of unborn babies developing serious … All medications have side effects, including Zofran. Selected from data included with permission and copyrighted by First Databank, Inc. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: Applies to ondansetron: injectable solution, intravenous solution, oral disintegrating strip, oral solution, oral tablet, oral tablet disintegrating, The most frequently reported side effects are headache, constipation, and diarrhea. Common side effects associated with Zofran include headache, drowsiness, constipation and the chills. Cerenex Pharmaceuticals, Research Triangle Pk, NC. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Giant Hives 10. Strativa Pharmaceuticals, a Division of Par Pharmaceuticals, Inc., Woodcliff Lake, NJ. If these effects persist or worsen, notify your doctor promptly. [Ref], Very common (10% or more): Headache (up to 27%), drowsiness/sedation (up to 23%), Common (1% to 10%): Dizziness, paresthesia, Uncommon (0.1% to 1%): Seizures, movement disorders/extrapyramidal reactions (oculogyric crisis/dystonic reactions, dyskinesia), Rare (0.01% to 0.1%): Grand mal seizures[Ref]. This drug is more popular than comparable drugs. Ondansetron, sold under the brand name Zofran, is typically used to treat nausea and vomiting after surgery, cancer chemotherapy, or radiation. Zofran side effects Get emergency medical help if you have signs of an allergic reaction to Zofran: rash, hives; fever, chills, difficult breathing; swelling of your face, lips, tongue, or throat. Ondansetron works in the stomach to block the signals to the brain that cause nausea and vomiting. Ondansetron is in a class of medications called serotonin 5-HT3 receptor antagonists. O 0. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. If you struggle with nausea … Seek immediate care if you experience an irregular heartbeat, shortness of breath, dizziness, or fainting while taking Zofran (ondansetron). It is ineffective for treating vomiting caused by motion sickness. It is also effective for treating gastroenteritis. Temporary Blindness 16. Zofran is the trade name for ondansetron. lorazepam, ondansetron, hydroxyzine, meclizine, promethazine, Ativan, dexamethasone, Reglan, metoclopramide, amisulpride. Doctors also prescribe it to pregnant women who have extreme or debilitating morning sickness. [Ref], Common (1% to 10%): Sensation of warmth/flushing, bradycardia, hypotension, arrhythmias, Uncommon (0.1% to 1%): Chest pain with/without ST segment depression, Rare (0.01% to 0.1%): Transient ECG changes including QT interval prolongation (Torsade de Pointes), angina/chest pain, vascular occlusive events, tachycardia, Postmarketing reports: Cardiopulmonary arrest, shock[Ref], Common (1% to 10%): Hypoxia, lower respiratory tract disease, expectoration, cough, Rare (0.01% to 0.1%): Bronchospasm/asthma, Postmarketing reports: Shortness of breath, laryngeal edema, stridor, laryngospasm[Ref], Laryngospasm occurred during allergic reactions in patients given the IV formulation. These side effects may go away during treatment as your body adjusts to the medicine. It can also cause other side effects. Although not all of these side effects may occur, if they do occur they may need medical attention.Check with your doctor immediately if any of the following side effects occur while taking onda… side effects The following have been reported as adverse events in clinical trials of patients treated with ondansetron, the active ingredient of ondansetron hydrochloride tablets. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. How long before a meal should you take ondansetron? Cerner Multum, Inc. "UK Summary of Product Characteristics." Headache occurred more often in the oral dissolving tablet formulation when taken with water. Along with its needed effects, ondansetron (the active ingredient contained in Zofran) may cause some unwanted effects. The most concerning side effects of Zofran include effects on the heart rhythm, a potential for birth defects and a condition known as serotonin syndrome. Applies to ondansetron: film, solution, tablet, tablet disintegratingOther dosage forms: 1. injection solutionAlong with its needed effects, ondansetron (the active ingredient contained in Zofran) may cause some unwanted effects. The National Institutes of Health lists the following as common side effects. Check with your doctor immediately if any of the following side effects occur while taking ondansetron: Some side effects of ondansetron may occur that usually do not need medical attention. Zofran Complaints Reported in Canada. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Liver failure and death have been reported in patients with cancer receiving potentially hepatotoxic/cytotoxic chemotherapy and antibiotics; however, the etiology of liver failure is unknown. The more common side effects of ondansetron can include: Zofran is a drug with problematic side effects. Acute Liver Failure 5. If experienced, these tend to have a Severe expression 1. Life Threatening Allergic Reaction 11. Side Effects What are the side effects of Ondansetron (Zofran)?. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. Zofran® May Cause Harmful Interactions With Certain Foods, Drugs, And Medical Conditions There's a lot of controversy surrounding the anti-nausea medication Zofran®, particularly when it's used by pregnant women. [Ref], Wound problems occurred at the surgical site in patients given this drug for the treatment of postoperative nausea and vomiting. Shock 13. It is unknown if Zofran enters breast milk. Although not all of these side effects may occur, if they do occur they may need medical attention. Ondansetron is used to prevent nausea and vomiting that is caused by cancer medicines (chemotherapy) or radiation therapy. Things to remember when you fill your prescription. This drug is more popular than comparable drugs. Transient visual disturbances, blurred vision, and transient blindness occurred predominantly during rapid IV administration. It is available in both brand and generic form. "Product Information. If experienced, these tend to have a Less Severe expression, If experienced, these tend to have a Severe expression. Side Effects. [Ref], Very common (10% or more): Eye disorder (up to 19%), Common (1% to 10%): Visual disturbance/transient visual disturbances (e.g., blurred vision), Very rare (less than 0.01%): Transient blindness, Frequency not reported: Swollen periocular area[Ref], Cardiopulmonary arrest and shock occurred during allergic reactions in patients given the IV formulation. Zofran (ondansetron) is a popular anti-nausea/vomiting drug, which has been widely prescribed off-label to pregnant women for morning sickness. Zuplenz (ondansetron)." Common Zofran side effects include: Ondansetron is used to prevent nausea and vomiting caused by cancer chemotherapy, radiation therapy, and surgery. The following article provides more detailed information on the use, side effects, and drawbacks of this drug. Hundreds of women have turned to the legal system to get justice and restitution for unexpected side effects that have changed lives forever. Most patients were receiving concomitant chemotherapy with cisplatin. Ondansetron orally disintegrating tablet may cause drowsiness. [Ref], Common (1% to 10%): Injection site reactions[Ref], Rare (0.01% to 0.1%): Immediate hypersensitivity reactions (sometimes severe), anaphylaxis/anaphylactoid reactions, Frequency not reported: Poor oral intake[Ref], 1. 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